Bone Abstracts

The present study figured out the relationship between social network and osteoporosis among elderly women. Social network could be beneficial to one’s health since it works as social capital providing several supports. On the other hand, social network can also be a source of social burden aggravating one’s health. To examine the seemingly contradicting associations, Korean Urban Rural Elderly Study (KURE) data was analyzed. There were 1938 older women aged over 65,...

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...

Objectives: Vertebral fracture (VF) is a hallmark of osteoporosis, and it increases morbidity, mortality and large amount of medical cost. In this study, we aimed to describe the treatment pattern and estimate the cost of VF among elderly patients in Korea.Methods: Using Korean national healthcare claims database, we analyzed a 2% sample of patients aged ≧ 50 years between years of 2008 and 2012. New VF was identified on the basis of selected ICD-10 c...

Introduction: A significant number of patient who have experienced previous surgical treatment for an osteoporotic hip fracture, experienced a subsequent hip fracture (SHF) on the opposite side. The incidence of asynchronous bilateral hip fractures is 1.7–14.8%. All hip fracture patients treated at five university hospitals in the Inchon and Bucheon area of Korea, were reviewed. The patients were divided into two groups, a group that had experienced subsequent hip fractur...

Introduction: The correlation between the occurrence of atypical femur fractures (AFFs) and prolonged bisphosphonate use has been reported in many studies. However, the incidence of AFFs is extremely low, which results in the lack of studies illuminating its treatment and clinical results so far. In this study, we aim to elucidate the clinical outcomes of bisphosphonate-associated AFFs and the clinical results depending on the bisphosphonate therapy period.<p class="abstex...

Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained. Here we demonstrate the therapeutic effect of AMD3100 in the treatment of ovariectomy-induced osteoporosis in mice. We found that treatment with AMD3100 resulted...

Background and objectives: Fracture in rheumatoid arthritis (RA) patient is more frequent than general population. One of the important reasons is use of glucocorticoid (GC) for treatment of RA. In this study, we aimed to identify the effect of GC on fracture of different site.Methods: Among RA patients &gE;19 years, we established a retrospective cohort using Korean national healthcare claims database from Jan 2010 to Dec 2010, and then followed up unti...

Introduction: Percutaneous vertebroplasty is a well known surgical method to put the bone cement at osteoporotic vertebrae. There was a few report concerning about bone cement related complication such as dislodgment of injected cement. There are some contradictory study for long term reaction to bone cement in osteoporotic bone, especially injected cement features. This study is to assess the radiographic features of patients who underwent percutaneous vertebroplasty (PVP) in...

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in leptin (LEP), its receptor (LEPR) and β adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.Methods: The LEP c.280G>A, LEPR c.326A>G, c.668A>G, c.1968G>C, c.2096C>T, ADRB2 c.46A>G, c.79C>G, c.718T>C, c....

Evidence indicates that dipeptidyl-peptidase 4 (DPP4) plays a distinct role in bone metabolism. However, there has been no report on the association, if any, between circulating DPP4 levels and osteoporosis-related phenotypes. This study aimed to determine if DPP4 predicts osteoporotic fracture (OF) risk in postmenopausal women. This case–control study was conducted in multiple centers in Korea. We enrolled 178 cases with OF and 178 age- and body mass index-matched contro...