Bone Abstracts

Background: Osteoporosis is not a homogenous disease. Riggs et al. identified two distinct types of osteoporosis, with different pathophysiology, patterns of bone loss and fracture types.Post-menopausal (PM) osteoporosis is triggered by withdrawal of the effect of oestrogen on bone, which leads to a sharp acceleration of bone turnover with an imbalance towards excessive osteoclastic activity. Senile osteoporosis in the old old (usually after the...

Objectives: Vitamin D dependent rickets type I (VDDR-I) is an autosomal recessive disorder with impaired activation of vitamin D, caused by mutations in CYP27B1. Characteristic clinical features are hypotonia, muscle weakness, growth failure, hypocalcemic seizures in early infancy, and radiographic findings of rickets. We aimed to describe the clinical and laboratory findings in a VDDR-1 case and to report a mutation in CYP27B1.Methods and results: The p...

Background: Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutation in the gene encoding the extracellular matrix protein fibrillin-1 (FBN1), leading to transforming growth factor-beta (TGF-β) signaling dysregulation. Although decreased axial and peripheral bone mineral density (BMD) has been reported in adults with MFS, data about the evolution of bone mass during childhood and adolescence are limited.Objectives: The aim of th...

Background: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in children and it is well known for its progressive deteriorating course. Nowadays, use of glucocorticoids is the gold standard of treatment for this group of patients as it can significantly prolong ambulation, decrease risk of scoliosis, and pulmonary functions. However, the use of glucocorticoid is associated with increased risk of vertebral and lower limb fractures, which could further acc...

Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. Increasing evidence indicates that a significant network connects synovitis and cartilage destruction during the progression of arthritis. We recently demonstrated that hypoxia-inducible factor (HIF)-2α causes RA and OA by regulating the expression of catabolic factors in fibroblast-like synoviocytes (FLS) or chondrocytes. To ...

Objectives: Poor bone health in boys with Duchenne Muscular Dystrophy (DMD) due to muscle weakness and glucocorticoid treatment is a major concern. This study assesses the bone health status in DMD boys with glucocorticoid treatment in a single centre.Methods: A retrospective chart review from January 2009 to January 2017 was undertaken on all DMD cases with active follow-up in a single paediatric unit in a University-affiliated hospital. We assessed the...

Fractures are very common and affect 2% of the population per annum. Fragility fractures represent the greatest unmet need and are associated with high rates of morbidity and mortality. Currently, there is no approved therapy for enhancing healing of fragility fractures. We previously reported that upregulation of the early inflammatory response following skeletal injury can promote fracture repair (Glass et al PNAS 2011). Inflammation represents the earliest response followin...

Delivery of recombinant human bone morphogenetic protein (rhBMP2) with various carriers has been showing the successful induction of bone formation in many bony defects, including oral and maxillofacial regions. However, effectiveness of the exogenous proteins, when repeatedly administered into different regions in an individual, has not been determined. The present study was aimed to examine alterations of ectopic or orthotopic bone generation and serum level of anti-BMP2 ant...

Background: In 2004, we reported a 48.1% prevalence of osteoporosis in an Ibansung cohort. The current prospective intervention study was undertaken in order to estimate the prevalence of osteoporosis from 2004 to 2015 and the increasing treatment rate of osteoporosis following osteoporosis screening tests with ultrasound bone densitometry and education in the same cohort.Methods: From November 1, 2014 to August 31, 2015, 960 adults ≥50 years of ag...

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