Bone Abstracts

Although trials have shown that exercise has positive effects on bone mineral density (BMD), not all exercise modalities are osteogenic and the majority of exercise trials have been conducted in older women. The aim of this study was to systematically review trials examining the effect of weight-bearing and resistance-based exercise modalities on the BMD of hip and lumbar spine of middle-aged and older men. Eight electronic databases were searched in August 2012. Only randomis...

Objectives: The aim of this study was to evaluate and assess the change in bone mineral density in OI children treated with BPs at Chris Hani Baragwanath Academic hospital (CHBAH), South Africa.Methods: Medical files of 104 OI patients who were seen at Metabolic Bone clinic from 01 January 2006 till 31 December 2015 were reviewed. DXA measurements were available on 33 patients that received bisphosphonates from baseline and during therapy at three time p...

The high prevalence of renal osteodystrophy (ROD) in pediatric renal transplant recipients has been linked to the duration on dialysis pre transplant, exposure to steroids, nutritional deficiencies, limitations in physical activity and ethnicity. The incomplete resolution of ROD in transplant recipients has been found to be associated persistent abnormalities in mineral metabolism associated with allograft dysfunction in the post transplant period.We hyp...

Biographical DetailsWim Van HulWim Van Hul is full professor of Molecular biology and genetics at the University of Antwerp, Belgium. He obtained a bachelor degree in Chemistry from the University of Louvain (Belgium) and a master degree in biochemistry. He obtained his PhD on molecular genetics in 1993 from the University of Antwerp. He started his...

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...

Biographical DetailsM van den Heuvel-Eibrink is Associate Professor of Pediatric Oncology at the Erasmus MC/Sophia Children’s Hospital, Rotterdam, The Netherlands. She began her medical career with an MD from the University of Utrecht and following a number of years of clinical work in the pediatric oncology field completed her PhD in Rotterdam in 2001. Since 2009 Dr M van den Heuvel...

Introduction: Despite similarities in upfront treatment, impairment of bone mineral density(BMD) varies in long-term adult survivors of childhood cancer (CCS). We studied for the first time whether genetic variation is involved in impairment of BMD in adult long-term CCS.Method: This cross-sectional single-center cohort study included 334 adult CCS (median follow-up time: 15.2 years (range 5.1–39.8); median age at follow-up: 26.1 years (range 18.1&#...

Biographical DetailsHans van LeeuwenHans (J.P.T.M.) van Leeuwen studied biology in Amsterdam, and did his PhD study on the mechanism of action of PTH in Leiden, The Netherlands. Currently he is professor at the Erasmus University Medical Center in Rotterdam, The Netherlands, leading the research program on Calcium and Bone Metabolism. Main research ...

About two decades ago, evidence was generated that canonical Wnt signaling plays an important role in bone accrual mainly based on the identification of mutations in genes from the Wnt pathway resulting in extremely low or high bone mass. Since then, it became clear that genetic variation in a lot of genes from this pathway have an influence on bone mass both in a number of skeletal dysplasias as well as in the general population. This is the case for a number of wnt ligands (...

Objectives: The obesity in children and adolescents is in an exponential rise, particularly in the United States. New research indicates that high adiposity could be detrimental for both bone and muscle, via fat infiltration in those tissues, leading to the osteosarcopenic obesity1. Therefore, healthy weight in children is crucial for bones and muscles. Our objective was to develop a music therapy program to improve children’s dietary and exercise habi...