Bone Abstracts

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Osteoporotic fractures are very common and represent an enormous unmet medical need. Our group has previously reported that addition of rTNF to the fracture site promotes fracture healing in C57/BL6 mice (Glass et al. PNAS 2011). Using a murine fracture model of endochondral healing, we observed that local addition of rTNF only accelerates fracture repair if administered within the first 24 h following injury. The optimal therapeutic dose is 1 ng. TNF is firs...

The impact of sex and maturation on trabecular (Tb) and cortical (Ct) microarchitecture in children and young adults has not been well established. The new second-generation high-resolution peripheral quantitative CT (HR-pQCT) scanner (XCT II, Scanco Medical) incorporates three important advances to provide greater spatial resolution, direct measures of Tb thickness and spacing and measures in the Ct midshaft. The aim of this study was to identify sex and maturation effects on...

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Recent meta-analyses of vitamin D without co-administration of calcium have not demonstrated fracture prevention, possibly through lack of power, inappropriate choice of doses, or failure to target the intervention to deficient populations. Bone mineral density (BMD) is able to detect biologically significant effects in much smaller cohorts, so is a relevant surrogate measure with which to re-assess the skeletal efficacy of these supplements. We searched Web of Science, Embase...

Objectives: Deteriorating bone mineral density and fragility fractures are common complications of Duchenne Muscular Dystrophy (DMD). This study aims to evaluate the effects of bisphosphonate therapy and testosterone supplementation (for pubertal induction) on the bone health of children with DMD.Methods: This retrospective cohort study examined the clinical records of children with DMD managed at the Neurogenetics and Endocrine clinics at The Children&#...

Objectives: To evaluate the diagnostic outcomes of massively parallel sequencing (MPS) and identify genotype-phenotype correlations in children and adolescents with recurrent fractures.Methods: A retrospective chart audit was conducted of children and adolescents referred to the endocrine clinic at a tertiary children’s referral hospital with a history of recurrent fractures. Phenotypic data including fracture history, bone mineral density (BMD) and...

Successful long-term, cementless fixation of human shoulder components in osteoporotic (OP) and osteoarthritic (OA) patients poses major challenges. The possibility that enhanced osseointegration may rely on both the region of bone targeted and its relationship with the vasculature remains unexplored. We hypothesise that bone cells derived from subchondral (SC), cortical (C) and trabecular (Trb) bone regions exhibit differing osteogenic potential, which will be diminished in b...

The relationship between bone formation and blood flow is unclear. Recently, PTH was reported to activate production of nitric oxide (NO), a potent vasorelaxing agent, in endothelial cells and we and others have confirmed a strong vasorelaxing action of PTH in vivo in the mouse. Here, we tested the hypothesis that a potent NO synthase inhibitor (L-NAME: NG-nitro-L-arginine methyl ester) may alter the effect of intermittent PTH (iPTH) on b...

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