Bone Abstracts

Osteoporosis and fragility fractures correlated, are a major clinical problem in older women and men and a major public health problem worldwide. As the population ages, the incidence of osteoporotic fractures is increasing. These fractures are associated with higher health care costs, physical disability, impaired quality of life, and increased mortality.Aim: evaluation of the frequency, type and age of onset of fragility fractures in 110 centenarians (...

Abstract unavailable....

Objective: Classical homocystinuria due to cystathionine beta-synthase (CBS) deficiency, is a rare autosomal recessively inherited disease characterized by the multiple involvement on different organs. While the most striking cause of morbidity and mortality is thromboembolism, patients develop a marked osteoporosis at early age along with many other skeletal abnormalities. As CBS normally converts homocysteine to cystathionine, the result of CBS deficiency is an accumulation ...

Teriparatide is the active fragment (1–34) of the endogenous human parathyroid hormone (PTH). Studies showed that chronic administration of PTH results in decreased bone mass while intermittent exposure to PTH activates osteoblast bone deposition. Most of the structural studies published so far about the effect of Teriparatide focused their attention on the amount of newly-deposed bone without investigating the quality of the newly-formed bone tissue; moreover, most of th...

Multiple myeloma is an incurable neoplastic disorder of plasma cells, which invade the bone marrow, secrete monoclonal immunoglobulins, and induce bone lesions, hypercalcemia, anemia and renal failure. The development of myeloma relies on vicious interactions with the bone microenvironment, a deeper knowledge of which is needed to identify prognostic markers and potential therapeutic targets. To achieve an unbiased, comprehensive assessment of the extracellular milieu of myelo...

see PP117....

Introduction: Hypovitaminosis D is observed in several rheumatic autoimmune diseases, including systemic sclerosis (SSc); nevertheless, data concerning the possible determinants of reduced serum vitamin D levels in this disease are not fully investigated. The aim of this study is to evaluate the relationship between BMD, body mass composition, skin sclerosis, and serum vitamin D levels in two subsets of SSc patients.Patients and methods: 55 Post-menopaus...

Introduction: Currently, osteoporosis is mainly diagnosed through dual-enargy X-ray absorptiometry (DXA). However, DXA cannot be used for early diagnoses through population mass screenings because of issues related to ionizing radiation employment. Aim of this study is to perform a preliminary clinical validation of a new ultrasound (US)-based method for vertebral densitometry.Methods: A total of 270 women were included in this study according to the fol...

Background: Cherubism is a rare autosomal dominant bone disease characterized by bilateral painless enlargement of the jaws, that typically first appear at the age of 2–7 years. In this condition the affected bone is replaced with fibrous tissue, giving the patient a cherubic appearance.Until now only 300 cases have been reported in the literature.Case report: A caucasian 4-year-old male child came to our Pediatric Clinic comp...

Background: Cabozantinib (CBZ) is a receptor tyrosine kinase inhibitor with activity against MET, VEGFR2, FLT3, c-KIT, and RET. Pre-clinical studies in models of prostate cancer bone metastasis demonstrated that CBZ treatment induced both a suppression of tumour growth and an alteration in bone remodelling, suggesting that both tumour and bone microenvironment represented potential CBZ targets. This is the first study exploring the potential direct activity of CBZ in bone usin...