Bone Abstracts

Biographical DetailsDr Brendan Lee is the Robert and Janice McNair Endowed Chair in Molecular and Human Genetics, Professor and Interim Chairman of the Department of Molecular and Human Genetics at Baylor College of Medicine. Dr B Lee co-directs the joint MD Anderson Cancer Center and Baylor College of Medicine Rolanette and Berdon Lawrence Bone Disease Program of Texas, and the Baylor Co...

Background: Mechanical stimulation is thought to be critical for bone anabolic activity. It is unclear how quickly the growing skeleton responds to additional externally-applied mechanical stimuli. We wished to determine the acute effect of a standardised mechanical stimulus to the growing skeleton.Objectives: To determine the acute time course and magnitude of bone’s response to whole body vibration (WBV) in pre-pubertal boys.<p class="abstext"...

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We have reported femoral osteopenia in short term-vitamin D restricted rats without deterioration in tibial cortical bone volume (CBV), geometry or strength1. This study aimed to establish the effect of extended vitamin D deficiency in aged rat tibial volume and strength. Female Sprague-Dawley rats (9 m, n=6/group) were fed a diet containing varying vitamin D3 (D) levels (0, 2, 12, and 20 IU/day) with either low (0.1%, LCa) or high (1%, HCa) diet...

The aim of this study was to evaluate the adsorption of salivary proteins on giomer (Beautifil II) and composite resin (Filtek Z350).Three discs (5 mm diameter and 1 mm height) were prepared for each material. Three discs were immersed in 1 ml? of human saliva within polyethylene tube and stored at room temperature. Evaluations were performed by Bradford method and SDS gel electrophoresis for analysis of salivary protein adsorbed on giomer and composite ...

Human skeletal dysplasias consist of over 450 distinct conditions that affect the development and maintenance of bone and cartilage. Broadly they can be characterized by those that affect primarily bone, i.e., the osteodysplasias, vs those that affect cartilage, i.e., the chondrodysplasia. However, the lines dividing these two are increasingly blurred as we recognized them to be a spectrum of osteochondrodysplasias. Importantly, the advent of next generation sequencing has led...

Low bone mass is common in thalassemia (Thal) and sickle cell disease (SCD). Bone pain is also reported, though its relationship to low bone mass has not been explored. The aims of this study were to determine the prevalence of vertebral height abnormalities (VHA) and evaluate the relationship between VHA, low bone mass and patient assessed pain in Thal and SCD. Data were collected from the Thalassemia Clinical Research Network Pain Survey study and CHRCO Clinical Bone Density...

Thalassemia (Thal) is a genetic disorder of hemoglobin synthesis. In its most severe form patients require chronic blood transfusions to sustain life leading to iron overload unless excess iron is removed by chelators. Deferasirox (DFX) and deferoxamine (DFO) are the two most common chelators. DFX has recently been shown to reduce osteoclast activity in vitro.Objective: To explore the association between chelation therapy, bone density and verte...

Purpose: The aims of this study were (1) to assess the topographical and chemical changes of Ca and Mg ion implantation procedures using plasma immersion ion implantation and deposition (PIIID) technique and (2) to evaluate cellular response of human bone marrow-derived mesenchymal stem cells (hBMMSCs) to Ca and Mg ion-implanted titanium surface, compared with resorbable blast media (RBM)-treated titanium surface by observing cell attachment, proliferation and gene expression ...

Autogenous bone graft has been used in the treatment of a fracture, non-union, and bone defect. However, bone graft substitutes have been developed and used because of the limited amount or donor site morbidity of the autogenous bone graft. Many kinds of bone graft substitutes including osteoconductive materials and osteoinductive materials are used for improving bone healing. Osteoconductive materials help to provide a three-dimensional structure to support the ingrowth of th...