Bone Abstracts

The problem of early diagnosis of rheumatoid arthritis remains an important area of research in rheumatology. We investigated changes in bone metabolism, bone mineral density in early rheumatoid arthritis (ERA; up to 12 months). Data were compared with changes in the MRI study of the dominant hand.We observed 24 patients with ERA, the average age – 33.6±5.7 years. The men were 6 (25%), women – 18 (75%). Bone mineral density (BMD) was deter...

Chronic liver diseases (CLD) leads to an imbalance of bone remodeling, bone mass decrease with the development of hepatic osteodystrophy, which is most often seen in osteoporosis. In the development of structural and functional deficiency of bone plays an important role of calcium–phosphorus homeostasis and coherence calcium-regulating hormones (CRH), which include parathyroid hormone (PTH) and active metabolites of vitamin D.The aim of this study w...

Backgound: Limited data are available on body composition of preterm compared to born at term infants. The aim of our study was to compare bone mass, fat mass-FM and free fat mass-FFM in preterm and term infants at 40th weeks of gestational age (GA).Methods: Thirty-four preterm infants (14M, 20F) born at 31.0±2.2 weeks of GA (range 26–36+3 weeks) and n=8 term neonates (4M, 4F) born at 39.7±1.0 weeks of GA underwent a to...

Objectives: Children and adolescents with chronic kidney disease (CKD) are at risk of developing CKD-mineral bone disorder (CKD-MBD). This study was designed to follow Swedish pediatric patients prospectively for 3 years after kidney transplantation regarding growth and skeletal development.Methods: The study group comprised 13 patients (4 females), 4–15 years of age. Growth, bone mineral density (BMD) and markers of bone and mineral metabolism were...

Objectives: Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease, mainly affecting preterm infants. NEC-survivors may have short or dysfunctional bowel with malnutrition as a result. Osteopenia of prematurity is well described among preterm infants. To the best of our knowledge there are no studies that follow preterm NEC-survivors to 5 years of age, regarding growth and bone mass. The aim was to study whether children diagnosed with NEC during their neonatal p...

Introduction: A retrospective analysis we previously performed on post-menopausal women showed that the addition of inulin (3 g) and soy isoflavones (40 mg) to daily calcium (500 mg) and vitamin D3 (300 UI) supplementation was able to increase calcium absorption by 60%, while reducing circulating parathormone and leaving vitamin D3 levels unchanged. Therefore, we tested whether such a mixture could affect also bone metabolism.Method...

Introduction: Bisphosphonates are drugs of first choice in the treatment of postmenopausal osteoporosis; they inhibit bone resorbtion.Aim: This study evaluates the efficiency of bisphosphonates (alendronic acid+cholecalciferol 70 mg/5600 IU per weekly vs risedronic acid 35 mg/weekly vs ibandronic acid 150 mg/monthly) after 1 year of therapy.Methods: We present the results of a retrospective study which included 40 women with postme...

Objective: The physis, or growth plate, is comprised of precisely organized chondrocytes that confer longitudinal growth of the bone. Multiple signaling pathways cooperate to regulate growth through their control of chondrocyte shape, polarity, proliferation, and differentiation.1,2 Disruption of these cellular events result in physeal defects, skeletal deformities, and abnormal limb growth. Loss of function mutations in Smad4, a common intracellular effector of all...

Background: The significant increase in the life expectancy of the patients with cystic fibrosis (CF) came with some costs, as new complications have emerged. Among endocrine disorders, CF-related bone disease (CFBD) is a leading complications reported in the adult patients.Objectives: Our study present the first results of the bone mass and body composition evaluation by DXA in a small group of Romanian children with CF treated in the author’s depa...

Objectives: To describe two familiar cases of Hajdu–Cheney syndrome, a rare genetic disorder associated with skeletal dysplasia, craniofacial abnormalities, short stature, acro-osteolysis and osteoporosis.Materials and methods: A 51-year-old woman (case 1) presented in our outpatient clinic with pseudo-clubbing of some fingers and toes. She was short (139 cm) and thin (34 kg). She had facial and cranial abnormalities: thin lips, long philtrum, full ...