Bone Abstracts

Bone metastasis is a frequent occurrence in cancer patients, with severe complications such as fracture, bone pain, and hypercalcemia. The pathogenesis of osteolyitc bone metastasis depends on cross-communications between tumor cells and various stromal cells residing in the bone microenvironment. Many of these interactions are mediated by tumor derived growth factors, cytokines, proteases, and other secreted and exosomal proteins. Using gene expression profiling and proteomic...

Osteogenesis imperfecta (OI) type VI is caused by recessive null mutations in SERPINF1, encoding pigment epithelium-derived factor (PEDF), an anti-angiogenic secretory glycoprotein. Dominant mutations in IFITM5, encoding BRIL (Bone Restricted Ifitm-Like), a transmembrane protein upregulated in osteoblasts during mineralization, cause either type V OI (c.-14C>T, addition of 5 amino acids on BRIL) or atypical type VI OI (...

Recent genetic studies in rodents have revealed that circulating serotonin plays a key role in regulating bone formation and skeletal mass. However, the reported effects of circulating serotonin on bone mass in humans have been conflicting. We determined whether circulating serotonin levels influenced the rate of bone loss and fractures in males.We assessed the effect of serum serotonin on bone loss rate in a population-based cohort of 202 ambulatory mal...

Objectives: This study was designed to investigate the prevalence of low bone mass, the influence of amenorrhea on bone mineral density (BMD), and the cause of amenorrhea that provoke the severe low bone mass in premenopausal women.Materials and methods: One hundred and seventy one women diagnosed with amenorrhea in premenopausal women were included in this study. All patients underwent history taking, gynecological examination, and check serum hormone l...

Introduction: To compare serum vitamin D levels in elderly patients with or without osteoporotic spinal compression fractures (OSCF) and to evaluate a correlation between serum vitamin D level and several variables such as age, and bone mineral density (BMD), bone turnover markers.Methods: The medical records of 78 patients with OSCF (fracture group) and 84 age-matched control patients who were diagnosed osteoporosis without OSCF (control group) were rev...

Introduction: To analyze clinical assessment and efficacy of once-yearly i.v. zoledronic acid for osteoporosis.Materials and methods: The subjects were 322 osteoporotic patients who received more than single infusion of zoledronic acid in our hospital from October 2008 to March 2011. On clinical assessment, the adherence was evaluated by measuring the rate of reinfusion. Adverse events were recorded for safety assessment. For efficacy assessment, the bon...

Purpose: The purpose of the present study was to characterize the extent of sarcopenia among orthopaedic surgery patients.Methods: This retrospective cross-sectional study identified 222 patients immediately after or before an orthopaedic surgery including elective total hip and knee arthroplasty and hip fracture surgery at a single institution. 364 patients from an outpatient department who did not have an orthopaedic surgery were also examined as a con...

Aging is associated with a loss of systemic bone mass and an increased risk of especially the spine and hip. Therefore bone loss of teeth and ridge resorption can occur in the mouth. However, results of several studies investing association between systemic bone density and oral health have varied. In this study, we investigated the relationship between osteoporosis and dental caries with the Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 2008&#1...

Sacral insufficiency fracture is known as a common cause of lumbosacral pain developed without evident trauma in patients with osteoporotic spinal compression fracture. The purpose of study was to investigate the incidence and predisposing factors of sacral insufficiency fracture accompanied by osteoporotic spinal compression fracture.We carried out a retrospective study of 949 patients who were measured bone mineral densitometry (BMD) and showed osteopo...

see P58....