Bone Abstracts

New treatment agents against osteoporosis may not only lead to an improved trabecular structure, but can probably also strengthen the cortex. To assess this treatment effects by means of QCT, one has to deal with significant partial volume effects observing this very thin, but compact structure. A new method for cortical thickness estimation has been developed using an analytical deconvolution approach. After estimating the point-spread-function (PSF) of a scanner/kernel combi...

Glucocorticoids (GCs) are widely used to treat acute and chronic inflammatory diseases such as acute lung injury (ALI) and rheumatoid arthritis (RA) and lead to multiple side effects including GC induced osteoporosis (GIO). Molecularly GCs act by binding to the GC receptor (GR), a ligand induced transcription factor. We discovered that pharmacologically GC exposure reprograms binding of GR monomers towards GR dimers (Genome Research 2015 25:836). Furthermore we challenged the ...

Aim: To investigate the acute effects of oral glucocorticoids in doses used in clinical practice on biochemical indices of function of osteoclasts, osteoblasts and osteocytes.Methods: In 17 adult patients suffering from various medical pathologies requiring systemic steroid therapy that were never before treated with glucocorticoids, the glucocorticoid treatment was initiated (mean prednisolone equivalent dose of 23.1±12.7 mg/day, range 10–50 m...

Objectives: To evaluate the effect of oral ibandronate on bone health in osteoporotic children and adolescents, as there are only scarce data regarding its use in pediatric population.Patients, materials, methods: We enrolled seven patients (six boys; one girl; mean age 15.3±3.8 years; range 8–18 years) with low bone mineral density (BMD) (mean 0.746±0.141 g/cm2; i.e. −3.3±1.5 S.D. z-score) and...

Patients with type 2 diabetes (T2DM) have an increased risk of hip and vertebral fractures compared to non-T2DM subjects. The bone mineral density (BMD) does not reflect the impaired bone quality in T2DM patients. The aim of the present study was to investigate the relationship between BMD and bone formation (N-terminal propeptide of type I procollagen, PINP; osteocalcin, OC) and bone resorption (cross-linked C-telopeptides of bone type I collagen, CTX) markers, as well as cha...

Objectives: While studies in adults with cystic fibrosis (CF) showed increased fracture risk and decreased bone mineral density (BMD), the results of the pediatric studies have been contradictory. Our aims were to assess volumetric BMD, bone geometry and the muscle–bone relation at the forearm in children with CF using peripheral quantitative CT (pQCT), and to correlate these bone parameters to pulmonary function.Methods: Fifty-three patients with C...

Uncarboxylated osteocalcin, allegedly via G-protein coupled receptors, interacts with adipocytes and pancreatic β-cells, thus affecting metabolic homeostasis. Here, we demonstrate that MK-7 directly and indirectly, via osteocalcin, modulates the endocrine functions of both β-cells and adipocytes.• It was shown (by applying the Mir@nt@n-based emulation algorithm) that MK-7 was involved in a network of intracellular regulat...

The study is aimed to evaluate body composition and bone status in adult patients with active juvenile idiopathic arthritis (JIA) untreated with tumor necrosis factor α inhibitors. Adult patients (12 males and 19 females) with JIA and 84 healthy age- and gender- matched controls were enrolled into the study. Body composition and areal bone mineral density (aBMD) at the lumbar spine, proximal femur, femoral neck, distal radius and total body were assessed using dual energy...

Objective: To find whether treatment with cholecalciferol and calcium in a group of vitamin D deficient women is associated with changes in muscular function, musculoskeletal pain, and fatigue.Design: Prospective interventional cohort study.Sample: A study group of 25 post partum women recruited and diagnosed with hypovitaminosis D during pregnancy.Setting: The study group was recruited 2006–2009 at two ...

Objectives: Increased fracture risk and decreased bone mineral density (BMD) have been demonstrated by several studies in Turner syndrome (TS). Affected females have short stature and present with primary amenorrhea. Good densitometric predictor of fractures and longitudinal data on BMD development in childhood and adolescence are still lacking.Patients and methods: Single tertiary care endocrinology center longitudinal study was performed. Peripheral qu...