Bone Abstracts

see PP350....

Background and aims: Cirrhosis and chronic pancreatitis (CP) are accompanied by inflammation and malnutrition. Both conditions may affect bone metabolism negatively and facilitate bone fractures. The objective of this study was to evaluate the risk of fractures among patients with CP or cirrhosis and the impact of fat malabsorption on fracture risk among patients with CP.Methods: Using the Danish National Patient Register, we did a retrospective cohort s...

Interference fit fixation of soft-tissue grafts is in clinical focus to allow anatomic graft fixation which increases stability and graft isometry. Although clinical data show promising results with different screw materials, the issue of biodegradability, handling and stability in the first weeks remain under demand. The purpose of the present study was to investigate anterior cruciate ligament (ACL) reconstruction radiologically, biomechanically and histologically using dire...

Many reports have proposed significant role of vitamin D on immune mediated disease. This study analyzed lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women to determine the potential effect of vitamin D on immune-mediated disease.On a prospective observational basis, we enrolled 31 postmenopausal women who underwent health checkup in our hospital. Peripheral blood drawn for the estimation of total T, B cell, NK cell cou...

Ankylosing spondylitis is a chronic inflammatory rheumatic disease, characterized by axial pain and osteoproliferation, leading to painful rigidity of the spine and disability. In contrast with this bone formation, bone loss is an early event in this disease, and an increased vertebral fracture risk (but not non-vertebral fracture risk) has been reported in these patients.Prospective studies have shown that potent anti-inflammatory drugs, such as anti-TN...

Celiac disease (CD) is a frequent cause of malabsortion in childhood and affects calcium and vitamin D absorption.Aim: Analyze the vitamin D levels and bone mineral density (BMD) at diagnosis in patients affected with CD, and the influence of the age of diagnosis in the clinical presentation.Patient: 52 patients (female: 26) were evaluated.Results: The percentage with vitamin D deficiency (<20 ng/ml) was ...

Molecules secreted by the osteoclast or ‘clastokynes’ are essential to stimulate bone formation by osteoblasts. Treatments with bisphosphates and Denosumab target osteoclast survival and differentiation. This suppresses bone turnover and is suspected to increase the risk of atypical fractures in the long term. A solution to overcome this is to develop strategies that target selectively the activity of osteoclasts without affecting their survival or differentiation. S...

Objective: Oosteoporoti fractures are a growing problem especially in aged societies of industrialized countries. Therefore, a clinical demand for synthetic bone graft substitutes is increasing. Despite the general success CPC showed clinically, development of CPC-based material by adding stronsium could improve its suitability to treat osteoporotic fractures.Methods: Sprague–Dawley rates model of induced osteoporosis via multi-deficiencies diet com...

Objective: To investigate i) the analytic stability of PTH in venous blood specimens in serum tubes processed at different time intervals after collection compared to immediately processed blood samples collected in K2EDTA tubes, and ii) whether storage of samples in serum tubes for 5 years at −20 °C had an effect on stability of PTH.Methods: Venous blood samples were collected from ten healthy Caucasian females. One K2EDTA tube and three seru...

Introduction: The purpose of this study was to evaluate whether daily treatment with 400 IU vitamin D3 was sufficient to maintain 25-hydroxyvitamin D (25(OH)D) concentrations above 60 nmol/l over a 3-year period. In addition, the study aimed to clarify if any differences existed in serum 25(OH)D between pre-supplemented women and women who already had serum 25(OH)D above 60 nmol/l at screening.Methods: Serum samples drawn from 251 postmenopaus...