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ba0005oc6.6 | Development and differentiation (or Aging) | ECTS2016

Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy

Sacitharan Pradeep Kumar , Zarebska Jadwiga , Gharios George Bou , Vincent Tonia , Edwards James

Ageing is universally linked to skeletal deterioration. Common mechanisms may control both processes, where dysregulation may predispose to bone loss and osteoarthritis (OA). The epigenetic modifier SirT1 controls lifespan and decreases with age. However, the role of SirT1 in joint disease is unclear. Human tissue samples, novel genetically modified mice, a surgical disease model and advanced cellular and molecular studies were employed to explore the hypothesis that SirT1 is ...

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Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy

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