Bone Abstracts

Introduction: Intravenous bisphosphonates (IB) and subcutaneous denosumab (SD) are potent antiresorptive agents widely used in the treatment of osteoporosis, Paget’s disease and metastatic malignancy. Several case reports have identified the risk of life-threatening hypocalcaemia with these treatments, particularly in the context of vitamin D deficiency and further highlighted by recent UKMHRA advice.Design: To optimise vitamin D status and decrease...

Purpose: PK-VF study, being conducted in 2007–2008 and 2012–2013, was aimed to investigate the prevalence and 5-year incidence of vertebral fractures (VFs) in postmenopausal women aged 50 years or older in Beijing, China.Methods: In the 2007–2008 survey, we randomly selected a community-based population of 1825 postmenopausal women, of whom 952 women also participated in the 2012–2013 survey. Adopting the same sampling strategies as 2...

Purpose: The aim of this 5-year prospective study was to investigate the association between type 2 diabetes mellitus (T2DM) and incident osteoporotic fracture (IOF) in Chinese postmenopausal women aged 50 years or older.Methods: We included 826 subjects, participating in both the baseline (2007–2008) and follow-up (2012–2013) studies. Based on the diagnosis of T2DM, subjects were first individualized into Non-T2DM and T2DM groups, which were t...