Bone Abstracts

Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones susceptible to fractures. No definite cure for OI exists. Bisphosphonates, although not implicitly recommended in children due to deficient efficacy and safety data, have been administered off-label to OI patients for over 20 years. Short-term adverse effects of intravenously administered bisphosphonates are generally mild. Although anemia is a known side effect of bisphosphonates in adults,...