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ba0005p360 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Warfarin use and changes in bone mineral density in the population-based canadian multicentre osteoporosis study (CaMos)

Vaninetti Nadine , Kirkland Susan , Thompson Kara , Theriault Chris , Prior Jerilynn , Kovacs Christopher , Adachi Rick , Towheed Tanveer , Leslie William , Davison K Shawn , Morin Suzanne , Goltzman David , Kaiser Stephanie

Background: Osteocalcin has an important role in bone metabolism. Uncarboxylated osteocalcin predicts risk for hip fracture and lower bone mineral density (BMD). Warfarin inhibits carboxylation of osteocalcin, providing a mechanistic link between warfarin and impaired bone metabolism. Studies examining the relationship between warfarin use and BMD have been inconsistent. The goal of this study was to further characterize this relationship.Population: CaM...

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Warfarin use and changes in bone mineral density in the population-based canadian multicentre osteoporosis study (CaMos)

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