ba0005p235 | Genetics and Epigenetics | ECTS2016
Pepe Jessica
, Bonnet Nicolas
, Herrmann Francois
, Biver Emmanuel
, Rizzoli Rene
, Chevelley Thierry
, Livio Ferrari Serge
Background: We previously reported that serum periostin levels are determined by additive genetic effects. Whether serum levels and/or SNPs in the periostin gene (Postn) contribute to bone microstructure however remains unknown.Aim: To investigate the association between periostin levels, Postn SNPs, bone-mass and bone microarchitecture in a cohort of postmenopausal women.Methods: A total of 648 postmenopausal women from the Geneva...