ba0001pp211 | Cell biology: osteoblasts and bone formation | ECTS2013
Coxon Fraser
, Douglass Angela
, Hughes Alun
, Helfrich Miep
, Seabra Miguel
, Tolmachova Tanya
The Rab family GTPases Rab27a and Rab27b play an important role in the trafficking of lysosome-related organelles in specialised cells, such as melanocytes. Since secretory lysosomes, also considered a lysosome-related organelle, are important for osteoclast and osteoblast function, we hypothesised that Rab27 plays a role in bone physiology. In support of this, a recent study demonstrated impaired transport of RANK ligand to the plasma membrane in osteoblasts from mice lacking...