Bone Abstracts

PTH replacement therapy in hypoparathyroidism (hypoPT) has become more accepted after proving successful in several clinical studies. Intact PTH (PTH1–84) was in 2012 withdrawn, leaving teriparatide (PTH1–34) the only therapeutic option available.All patients with postoperative HypoPT who changed medication from PTH1–84 (100 μg) to PTH1–34 (20 μg), after at least 12 months of conve...

Background: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (Ps-HypoPT) are both rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively.Studies on Quality of Life, QoL, are sparse, but studies have shown an increased risk of fatigue and depression.Methods: Using the Danish version of SF36v2 and WHO-5 Well Being Index, we investigated the physical and mental QoL among patients with NS-Hypo...

In previous studies, discrepant effects of TSH and thyroid hormones on bone have been reported. While low TSH and high thyroxine (T4) levels increase bone turnover, a recent study suggested a positive association between triiodothyronine (T3) levels and mineral deposition in bone. No data are available on bone architecture and strength in relation to thyroid status.Aim: Using a cross-sectional design, we determined whether bone dens...

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

Background: Hypoparathyroidism (HypoPT) is a rare disease, characterized by low plasma levels of Parathyroid hormone and calcium. Furthermore it is characterized by high BMD and very low bone turnover.Aim: We studied risk of fracture in patients with postsurgical HypoPT due to non-malignant diseases compared with an age- and gender-matched control group.Method: We performed a controlled cohort study. Patients diagnosed with HypoPT ...

Background: DXA scan has for many years been gold standard when analyzing areal bone mineral density (aBMD) in osteoporotic patients. Risk of fractures increases as aBMD declines. However, although risk of fracture is highest in patients with osteoporosis, it is well known that the majority of fragility fractures actually occur in patients with osteopenia rather than osteoporosis. As aBMD is a projected two dimensional imaging technique it does not differentiate between cortic...

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Context: Impairment of muscle function and strength in patients with primary hyperparathyroidism (PHPT) is rarely addressed although decreased muscle function may contribute to increased fracture risk in PHPT.Objective: We aimed to assess changes in muscle strength, muscle function, postural balance, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.<p class="abs...

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.Age and gender matched patients on treatment for HypoT+PT and ...

Introduction: In spite of the frequent encounter of ‘asymptomatic’ primary hyperparathyroidism (PHPT), the patients often describe various relevant improvements postoperatively suggesting a subclinical biological effect of elevated PTH or hypercalcaemia.Materials and methods: To evaluate muscle function, postural stability, and quality of life (QoL) in untreated PHPT, we assessed maximal isometric muscle strength in upper and lower extremities,...