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ba0003oc2.2 | Osteoporosis epidemiology | ECTS2014

Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

van Wijngaarden JP , Swart KMA , Enneman AW , Dhonukshe-Rutten RAM , van Dijk SC , Ham AC , Brouwer-Brolsma EM , van der Zwaluw NL , Sohl E , van Meurs JBJ , Zillikens MC , van Schoor NM , van der Velde N , Brug J , Uitterlinden AG , Lips P , de Groot CPGM

Background: Elevated plasma homocysteine levels are a risk factor for osteoporotic fractures. Supplementation with vitamin B12/folic acid lowers homocysteine levels. This study aimed to determine whether vitamin B12/folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic elderly.Methods: B-PROOF is a double-blind, randomized, placebo-controlled trial including 2 919 participants aged &gE;65 years with elevated homocyste...

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Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

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