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ba0001pp28 | Arthritis and other joint diseases: translational and clinical | ECTS2013

The glutamate receptor antagonist NBQX alleviates inflammation, pathology and gait abnormalities in rat antigen induced arthritis

Bonnet Cleo , Williams Anwen , Gilbert Sophie , Harvey Ann , Evans Bronwen , Mason Deborah

Objectives: Synovial fluid glutamate concentrations increase in various arthritides. Activation of kainate (KA) and AMPA glutamate receptors (GluRs) increase interleukin 6 (IL6) release and cause arthritic pain respectively. GluR antagonists represent potential peripheral treatments for inflammatory arthritis and inflammatory mechanisms that contribute to osteoarthritis (OA). We hypothesised that AMPA and KA GluRs are expressed in arthritic joint tissues and that peripheral ad...

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ba0001pp29 | Arthritis and other joint diseases: translational and clinical | ECTS2013

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

Gilbert Sophie , Nowell Mari , Bonnet Cleo , Ladiges Warren , Morton John , Duance Vic , Mason Debbie

Objective: The protein kinases, PKR, and PERK have been implicated in pro-inflammatory cytokine-mediated cartilage degradation in vitro and endoplasmic reticulum stress-induced arthritis respectively. The objective of this study was to establish whether loss of P58IPK, an inhibitor of PKR and PERK, results in a degenerative joint phenotype in vivo.Methods: Sections of knee joints from P58IPK-null and wild-type mice...

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Bone Abstracts

The glutamate receptor antagonist NBQX alleviates inflammation, pathology and gait abnormalities in rat antigen induced arthritis

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

BiosciAbstracts

Bone Abstracts

The glutamate receptor antagonist NBQX alleviates inflammation, pathology and gait abnormalities in rat antigen induced arthritis

A deletion mutation of the gene P58IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

BiosciAbstracts

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice