Bone Abstracts

Background: The incidence and prevalence of gout have markedly increased over the last few decades in keeping with the rise in prevalence of obesity and metabolic syndrome. The management of gout in patients with associated metabolic syndrome and comorbid illnesses such as renal impairment was difficult because of limited treatment options. Recent efficacy and safety data favour lower over higher doses of colchicine, and oral corticosteroids over non-steroidal anti-inflammator...

Introduction: Niemann–Pick disease (NPD) is a rare autosomal recessive lysosomal lipid storage disorder. It is caused by mutations of genes which products are involved in the metabolism of sphingolipids. Their dysfunction causes sphingomyelin to accumulate in different organs which leads to progressive multisystemic disorder. Types A and B NPD are caused by mutations in sphingomyelin phosphodiesterase-1 gene with deficiency of acid sphingomyelinase (ASM). Types C and D NP...

Introduction: Obstructive sleep apnea (OSA) is a common sleep-related respiratory disorder characterized by repeated episodes of apnea and hypopnea resulting in sleep fragmentation, nocturnal hypoxia and hypercapnia, and excessive daytime sleepiness. OSA has recently become a well-recognized problem in view of its high prevalence in the general population. OSA is associated with many endocrine disorders (hypogonadotropic hypogonadism, hypercortisolism, glucose intolerance). Th...