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Bone Abstracts

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ba0003OP27 | Pre-Clinical | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

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ba0003pp416 | Steroid hormones and receptors | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead to multiple side effects including glucocorticoid induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by the glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation of genes is causing side effects.Using conditional and function selective mutant mic...
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Bone Abstracts
ISSN 2052-1219 (online)
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