Bone Abstracts

A decrease or absence of beta-globin production in erythroid cells causes a hereditary anemic disorder known as beta-thalassemia, which is associated with ineffective erythropoiesis, iron overload, growth retardation, osteopenia, and osteoporosis. Our recent investigation revealed that beta-thalassemia led to osteoclast-mediated bone resorption and the impaired intestinal calcium absorption, the latter of which modestly responded to conventional 1,25-dihydroxyvitamin D3</...