ba0001pp208 | Cell biology: osteoblasts and bone formation | ECTS2013
Shah Mittal
, Gburcik Valentina
, Sankey Andrew
, Reilly Peter
, Emery Roger
, Clarkin Claire
, Pitsillides Andrew
Successful long-term, cementless fixation of human shoulder components in osteoporotic (OP) and osteoarthritic (OA) patients poses major challenges. The possibility that enhanced osseointegration may rely on both the region of bone targeted and its relationship with the vasculature remains unexplored. We hypothesise that bone cells derived from subchondral (SC), cortical (C) and trabecular (Trb) bone regions exhibit differing osteogenic potential, which will be diminished in b...