ba0005p101 | Cancer and bone: basic, translational and clinical | ECTS2016
Rouach Vanessa
, Goldshtein Inbal
, Chodick Gabriel
, Catane Rafael
, Stern Naftali
, Cohen Daniel
Background: Bisphosphonates (BP) are widely used in osteoporosis treatment. By inhibiting the mevalonate pathway, bisphosphonates may affect cell function and survival, including the viability of tumor cells. Recently, a protective effect of bisphosphonates on breast cancer risk has been suggested by several studies, which were unable to exclude the possibility of a confounder effect due to low cumulative exposure to estrogen in osteoporotic women vs controls.<p class="abs...