ba0001pp387 | Osteoporosis: pathophysiology and epidemiology | ECTS2013
Ma Vivian
, Li Xiaojuan
, Sigurdsson Sigurdur
, Eriksdottir Gudny
, Hauksdottir Alda
, Palermo Lisa
, Hue Trisha
, Lang Thomas
, Harris Tamara
, Rosen Clifford
, Vittinghoff Eric
, Siggeirsdottir Kristin
, Sigurdsson Gunnar
, Oskarsdottir Diana
, Gudnason Vilmundur
, Schwartz Ann
Previous studies found a negative correlation between vertebral bone marrow fat (MF) and bone density (BMD). Proposed mechanisms for this include i) a shift in stem cell lineage allocation from osteoblasts towards adipocytes, and ii) an increase in osteoclast-promoting cytokines with greater MF. However, little is known about the relationship between MF and bone markers. To assess these relationships in older adults, we used data from the AGES-Reykjavik cohort. MF was measured...