Bone Abstracts

Fibrous dysplasia of bone (FD) is a rare bone disease affecting one or several bones, due to a somatic mutation of GNAS responsible for abnormal differentiation of the osteoblastic cell lineage. The bone lesions may be associated with bone pain, fracture, deformity and neurologic compression. McCune-Albright syndrome is an association of FD, endocrine complications - mainly peripheral precocious puberty - and café-au-lait cutaneous spots.The mutated...

Fibrous dysplasia of bone (FD) is a rare inherited but sporadic bone disease that can be responsible for bone pain, fracture and bone deformity. The prognosis may be difficult to establish because of the wide spectrum of disease severity, with patients benign forms of the disease and some others who are severely affected.We have analyzed the data from the French National reference center for FD. We have established a database from electronic medical reco...

Objectives: Bone disease is now well described in cystic fibrosis adult patients. CF bone disease is multifactorial but many studies suggested the crucial role of inflammation and chronic pulmonary infection. The objectives of this study were to assess the prevalence of osteoporosis in a current adult CF population and to examine its relationship with infections and inflammation.Methods: Patients were recruited in the adult CF Lyon Centre and assessed in...

Background: Bone fragility and vascular calcifications are to the two main morbidities of the mineral and bone disorders associated with chronic kidney disease (CKD), resulting from a combination of abnormalities such as impaired GH axis, vitamin D deficiency, hyperparathyroidism, increased FGF23 levels, hypogonadism, denutrition and drug toxicity.Methods: In a single-centre ancillary study of the longitudinal prospective European 4C study (Cardiovascula...

Beside the bone mass, structural changes are important determinants of the bone strength. Patients with osteoarthritis (OA) seem protected against femoral neck (FN) fracture. When compared to osteoporosis, FN in OA are characterized by a higher bone mass and a better trabecular microarchitecture (Blain et al., 2008, Boutroy et al., 2011). The presence of microcracks is one of the determinants of the bone strength. The aim of this study was to evaluate the mic...

Background: While the relationship between visceral (VFAT) and subcutaneous (SFAT) fat mass with cardiometabolic risk has been demonstrated in adults, fat mass evolution during teenagehood remains poorly explored and usually assessed with irradiative (CT) or expensive (MRI) techniques. Our aim was to evaluate a novel technique derived from DXA to assess VFAT and SFAT in healthy teenagers.Subjects and methods: Healthy teenagers from the VITADOS study unde...

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Odanacatib (ODN) is an orally-active cathepsin K inhibitor being developed for the treatment of postmenopausal osteoporosis. This study evaluated the effects of ODN 50mg once weekly on BMD, bone turnover markers and safety in patients previously treated with alendronate (ALN).This was a randomized, double-blind, placebo-controlled, 24-month study. The primary endpoint was % change from baseline at month 24 of femoral neck (FN) BMD. Postmenopausal women (...

Patients with improved health understanding have greater autonomy over, and motivation towards, health-related lifestyles. We compared self-perceived fracture risk and 3-year incident fracture rates in postmenopausal women for a range of co-morbid diseases using data from the Global Longitudinal study of Osteoporosis in Women (GLOW).GLOW is an international cohort study involving 723 physician practices across 10 countries in Europe, North America, Austr...