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ba0002oc4 | Epidemiology | ICCBH2013

Maternal antenatal 25(OH)-vitamin D status is associated with offspring muscle strength at 4 years of age

Moon Rebecca , Sayer Avan A , Ntani Georgia , Davies Justin , Robinson Sian , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Objectives: Serum 25(OH)-vitamin D (25(OH)D) concentration is known to influence muscle function in postnatal life. Maternal 25(OH)D status during pregnancy has been implicated in the fetal programming of bone and fat mass, but little is known about its role in determining offspring muscle development. We investigated the associations between maternal serum 25(OH)D concentration in pregnancy and offspring muscle mass and strength at 4 years.Materials and...

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ba0006oc4 | (1) | ICCBH2017

25-hydroxyvitamin D response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants: findings from the MAVIDOS trial

Moon Rebecca , Harvey Nicholas , Cooper Cyrus , D'Angelo Stefania , Curtis Elizabeth , Crozier Sarah , Robinson Sian , Graham Nikki , Holloway John , Bishop Nicholas , Kennedy Stephen , Papageorghiou Aris , Schoenmakers Inez , Fraser Robert , Gandhi Saurabh , Prentice Ann , Inskip Hazel , Javaid Kassim

Objectives: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with 25-hydroxyvitamin D (25(OH)D) status, but these relationships have not been examined in pregnancy or following antenatal vitamin D supplementation. We assessed whether SNPs in DHCR7 (7-dehydrocholesterol reductase), CYP2R1 (25-hydroxylase), CYP24A1 (24-hydroxylase) and GC (Vitamin D binding protein) were associated with the re...

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Bone Abstracts

Maternal antenatal 25(OH)-vitamin D status is associated with offspring muscle strength at 4 years of age

25-hydroxyvitamin D response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants: findings from the MAVIDOS trial

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