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ba0003pp13 | Arthritis and other joint diseases: translational and clinical | ECTS2014

RANK expression is reduced in circulating monocytes from ankylosing spondylitis patients

Perpetuo Ines Pedro , Caetano-Lopes Joana , Vieira-Sousa Elsa , Campanilho-Marques Raquel , Ponte Cristina , Canhao Helena , Ainola Mari , Fonseca Joao Eurico

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RAs main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients monocytes receive reduced osteoclastogenic stimuli and...

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ba0001pp482 | Other diseases of bone and mineral metabolism | ECTS2013

Zoledronate efficacy and safety in active Paget's disease: long-term follow-up and retreatment in clinical practice

Vieira-Sousa Elsa , Rodrigues Ana , Caetano-Lopes Joana , Capela Susana , Ramos Filipa , Figueira Ricardo , Joaquim Polido-Pereira1 , Ponte Cristina , Raquel Campanilho-Marques1 , Barros Rita , Romeu Jose Carlos , da Silva Jose Alberto Pereira

Background: Zoledronate, a third generation bisphosphonate, has showed high efficacy in the inhibition of bone resorption. The objective of this observational study was to assess short and long-term efficacy and safety of zoledronate in the treatment of active Pagets disease (PD).Methods: Patients with active PD treated with zoledronate 5 mg were consecutively recruited. Clinical and laboratory parameters were determined before, at 3 and every 6 mo...

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Bone Abstracts

RANK expression is reduced in circulating monocytes from ankylosing spondylitis patients

Zoledronate efficacy and safety in active Paget's disease: long-term follow-up and retreatment in clinical practice

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