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ba0005p237 | Genetics and Epigenetics | ECTS2016

Association among oxidative stress, Wnt signaling and trabecular bone microstructure in osteoporosis and osteoarthritis

Giner Merce , Miranda Cristina , Jose Montoya M. , Portal Sergio , Angeles Vazquez M. , Jose Miranda M. , Esbrit Pedro , Perez-Cano Ramon

Experimental studies suggested that both, oxidative stress and the Wnt pathway, are important factors in the regulation of bone remodeling. Thus, low antioxidant levels and elevated markers of Wnt pathway inhibitors (sclerostin) levels are associated with a reduced bone mineral density and increased risk of osteoporotic fracture. Whether oxidative stress and the Wnt pathway are related to fracture risk is poorly understood.M&M: Cross-sectional study ...

ba0005p234 | Genetics and Epigenetics | ECTS2016

SNP regulation of miRNA expression and its association with osteoporosis

De-Ugarte Laura , Caro-Molina Enrique , Rodriguez-Sanz Maria , Garcia-Perez M A , Olmos J M , Sosa-Henriquez Manuel , Perez-Cano Ramon , Gomez-Alonso Carlos , Del Rio Luis , Mateo-Agudo Jesus , Navarro-Casado Laura , Gonzalez-Macias Jesus , Del Pino-Montes Javier , Munoz-Torres Manuel , Diaz-Curiel Manuel , Malouf Jorge , Perez-Catrillon J L , Nogues Xavier , Garcia-Giralt Natalia , Diez-Perez Adolfo

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotype variability. The aim of this study was to identify osteoporosis-related SNPs by affecting the expression levels of mature microRNAs.The first approach was to perform an association analysis of putative functional SNPs located in pri-miRNA sequences of bone-related microRNAs with the lumbar spine and femoral neck (FN) bone mineral den...

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Association among oxidative stress, Wnt signaling and trabecular bone microstructure in osteoporosis and osteoarthritis

SNP regulation of miRNA expression and its association with osteoporosis

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