Bone Abstracts

Bone marrow is composed of cells developed within the marrow compartment as well as blood supplied from the general circulation. Bone tissue is affected by cytokines within the bone marrow.We investigated if the levels of different bone acting cytokines differ between bone marrow and blood from the peripheral circulation.Fifty-three healthy postmenopausal women participated in a study designed to evaluate the effect of rosiglitazon...

Background: Clinical studies suggest that vitamin K2 prevents bone loss and may protect against fractures. Vitamin K is a cofactor in the carboxylation of Osteocalcin (OC). Carboxylated OC promotes mineralization of bone. The aim of the study was to investigate the effect of vitamin K2 on osteocalcin, bone mass and -quality.Methods: We conducted a randomized placebo-controlled double-blinded clinical trial, in which 142 postmenopausal osteopenic women we...

see P393....

Background: Resveratrol (RSV), a natural polyphenolic compound, stimulates osteoblasts and inhibits osteoclast activation in vitro. Conflicting results have emerged from short-term studies in rodents but a recent study in men suggests a positive effect on BMD.Aim: To evaluate effects of short- and long-term high-dose RSV supplementation on bone in immobilized and non-immobilized rats.Methods: A total of 72 female Wistar ra...

Background: Resveratrol (RSV) is a natural polyphenolic compound, found in fx grapes, which possesses anti-inflammatory properties. RSV inhibits osteoclast activity and promotes osteoblastogenesis in vitro. Furthermore, RSV protects against bone loss after ovarectomy and immobilization in animal models. RSV treatment of obese men for 4 weeks resulted in an increase in bone specific alkaline phosphatase (BAP).Hypothesis: Low-grade inflammation is...

Despite the substantial preclinical evidence for a positive effect of the polyphenolic compound resveratrol, human data are very scarce, and currently no clinical data addressing the potential impact on bone metabolism have been published. In the present study we addressed this issue by testing a panel of bone specific biomarkers in order to identify potential bone metabolic effects of resveratrol in human subjects. In a randomized, placebo-controlled, double-blinded and paral...