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ba0003pp39 | Bone development/growth and fracture repair | ECTS2014

Bone shaft revascularization after marrow ablation is dramatically accelerated in BSP−/− mice, along with faster haematopoietic recolonization

Bouleftour Wafa , Granito Renata Neves , Bossche Arnaud Vanden , Sabido Odile , Roche Bernard , Thomas Mireille , Linossier Marie-Therese , Aubin Jane , Lafage-Proust Marie-Helene , Vico Laurence , Malaval Luc

The bone organ integrates the activity of bone tissue, bone marrow, and blood vessels and the factors ensuring this coordination remain ill defined. Bone sialoprotein (BSP) is with osteopontin (OPN) a member of the small integrin binding ligand N-linked glycoprotein (SIBLING) family, involved in bone formation, hematopoiesis, and angiogenesis. In rodents, bone marrow ablation induces a rapid formation of medullary bone which peaks by ~8 days (d8) and is blunted in BSP...

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Bone Abstracts

Bone shaft revascularization after marrow ablation is dramatically accelerated in BSP−/− mice, along with faster haematopoietic recolonization

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