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ba0001pp377 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Effect of glucocorticoid treatment on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone turnover and bone mass

Gifre Laia , Peris Pilar , Ruiz-Gaspa Silvia , Monegal Ana , Nomdedeu Benet , Guanabens Nuria

Wntβ-catenin signalling and its antagonists (sclerostin and Dkk-1) play an important role in the regulation of bone mass and osteoblastogenesis. Glucocorticoid therapy (GCCT) is a well known factor related to decreased bone formation and osteoporosis development. Therefore, we analyzed the effect of GCCT on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone mass and bone turnover.Methods: 22 patients (11M/11F, age...

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Effect of glucocorticoid treatment on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone turnover and bone mass

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