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ba0003OP21 | Pre-Clinical | ECTS2014

Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

Kalyvioti Eleni , Kypreos Kyriakos , Papachristou Nicholas , Orkoula Malvina , Triantaphyllidou Irene-Eva , Blair Harry , Papachristou Dionysios

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ba0003OP22 | Pre-Clinical | ECTS2014

Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

Papachristou Nicholas , Kalyvioti Eleni , Triantaphyllidou Irene-Eva , Blair Harry , Kypreos Kyriakos , Papachristou Dionysios

see PP291....

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ba0003pp290 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

Kalyvioti Eleni , Kypreos Kyriakos , Papachristou Nicholas , Orkoula Malvina , Triantaphyllidou Irene-Eva , Blair Harry , Papachristou Dionysios

Introduction: Recent data suggest that lipid metabolism imbalances affect osteoblast and osteoclast function resulting in altered bone mass quality and quantity. Here we investigated the role of apolipoprotein A-I (apoA-I), key-element in HDL biogenesis in the pathogenesis of osteoporosis in mice.Materials and methods: Lumbar vertebrae and femora from apoA-I deficient (ApoA-I−/−) and WT (ApoA-I<s...

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ba0003pp291 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

Papachristou Nicholas , Kalyvioti Eleni , Triantaphyllidou Irene-Eva , Blair Harry , Kypreos Kyriakos , Papachristou Dionysios

Introduction: Recent data suggest that lipid metabolism imbalances affect bone cell function and therefore may result in the development of osteoporosis. We investigated the role of apolipoprotein-E (ApoE), a plasma protein playing cardinal role in lipoprotein metabolism, in the regulation of osteoblast and osteoclast function and the pathogenesis of osteoporosis.Material and methods: We used apoE deficient (ApoE−/−) and C57BL/6 (c...

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Bone Abstracts

Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

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