ba0001oc6.6 | Mineralisation and energy metabolism | ECTS2013
Oldknow Karla
, Morton Nik Morton's
, Yadav Manisha
, Rajoanah Sophie
, Huesa Carmen
, Bunger Lutz
, Ferron Mathieu
, Karsenty Gerard
, MacRae Vicky
, Milan Jose Luis
, Farquharson Colin
Genetic approaches to bone physiology utilising judicious gain and loss of function models have identified bone as an endocrine organ, being involved in the regulation of energy metabolism and reproduction. Recent advances expand our understanding and identify a new and unconventional role of bone beyond its classical functions. PHOSPHO1 is a bone specific phosphatase with a recognised role in bone mineralisation, but our present studies have now identified a novel role for PH...