ba0003oc1.6 | Phosphate metabolism, fracture repair and osteoarthritis | ECTS2014
Sousa Daniela M
, McDonald Michelle M
, Mikulec Kathy
, Peacock Lauren
, Little David G
, Herzog Herbert
, Lamghari Meriem
, Baldock Paul A
Recent studies have demonstrated that the global or osteoblast-specific deletion of neuropeptide Y Y1 receptor (Y1R), as well as the pharmacological blockade of Y1R, leads to pronounced anabolic effects in bone metabolism. This suggests that anti-Y1R drug therapy might have clinical applications for the prevention/recovery of bone loss occurring in osteoporosis. Given the high fracture incidence in this target population, it remained...