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ba0005p238 | Genetics and Epigenetics | ECTS2016

Genetic variants at the Wnt/β-catenin and oestrogen receptor signalling pathways are associated with low bone mineral density in dancers

Amorim Tania , Duraes Cecilia , Maia Jose , Carlos Machado Jose , Nogueira Luisa , Adubeiro Nuno , Flouris Andreas D. , Metsios George S. , Marques Franklim , Wyon Matthew , Koutedakis Yiannis

Purpose: Research suggests that dancers are at higher risk of developing low bone mineral density (BMD) compared with the general population. However, the associated factors contributing to low BMD in dancers are not fully understood. We aimed to assess the association of single-nucleotide polymorphisms (SNPs) in the Wnt/β-catenin and oestrogen receptor (ER) signalling pathways with low BMD in dancers.Methods: A genetic association study was conduct...

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Genetic variants at the Wnt/β-catenin and oestrogen receptor signalling pathways are associated with low bone mineral density in dancers

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