Bone Abstracts

Background: Alkaline phosphatase (ALP) has an essential role in bone mineralization. ALP is attached to the surface of matrix vesicles (MVs) in which hydroxyapatite crystals are initially formed. Formation of a tentative collagen–ALP complex may be an early step in the calcification process. The present study was designed to investigate the binding properties of different ALPs to collagen present in bone and cartilage, i.e. types 1 and 2 collagen.Me...

Objectives: Children and adolescents with chronic kidney disease (CKD) are at risk of developing CKD-mineral bone disorder (CKD-MBD). This study was designed to follow Swedish pediatric patients prospectively for 3 years after kidney transplantation regarding growth and skeletal development.Methods: The study group comprised 13 patients (4 females), 4–15 years of age. Growth, bone mineral density (BMD) and markers of bone and mineral metabolism were...

Renal osteodystrophy encompasses the bone histologic abnormalities seen in patients with chronic kidney disease (CKD). The bone-specific alkaline phosphatase (BALP) isoform B1x is exclusively found in serum of some CKD patients. The aim of this study was to examine the relationship between serum BALP isoforms and histologic abnormalities of bone in patients with CKD on chronic dialysis (CKD-5D).Anterior iliac crest bone samples from 40 CKD-5D patients we...

Objectives: Anorexia nervosa (AN) is a life-threatening eating disorder often associated with reduced bone mass. The aim of the present study was to investigate vitamin D status and the association with BMI, fat mass and bone mineral density (BMD) during a novel intensive nutrition therapy in young AN women.Methods: Twenty-five female AN patients (20.1±2.3 years, BMI 15.5±0.9 kg/m2) admitted to a specialised inpatient eating disorder...

Objectives: Patients with anorexia nervosa (AN) are at high risk of reduced bone mass. The aim of this intervention study was to investigate the long-term effects on bone and body composition three years after intense weight gain therapy.Methods: Twenty-five female AN patients, mean age 20.1 years, mean BMI of 15.5 kg/m2, were included. Twenty-two patients fulfilled the treatment for 12 weeks with a high-energy diet. Body composition and bone ...

Objectives: To study acceptance and the effects on bone during a 6-month whole body vibration (WBV) therapy in severely disabled children.Methods: Nineteen patients, age 5–16 years, with severe motor disabilities completed the 6-month WBV therapy standing on a self-controlled dynamic platform with vibration, jumps and rotation. The WBV was performed twice per week at 40–42 Hz. Bone mass and biochemical markers were measured at start and after 6...

Objectives: Cross-sectional studies show that exercise may have positive effects on bone outcomes in youth. However, there is no evidence from longitudinal studies, which type of sports can induce improvements in bone acquisition in adolescent athletes. Therefore, this study aimed to investigate the longitudinal differences in bone acquisition and bone metabolism between adolescent males participating in osteogenic (football) and non-osteogenic (swimming, cycling) sports compa...