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ba0005cabs.oc1.1 | Oral Communications | ECTS2016

Secreted YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases

Bettencourt Maria , Ferreira Arlindo , Alho Irina , Lucia Costa Ana , Sousa Ana Rita , Mansinho Andre , Abreu Catarina , Pulido Catarina , Macedo Daniela , Vendrell Ines , Pacheco Teresa , Costa Luis , Casimiro Sandra

YB-1 (Y-box binding protein 1) is a multifunctional cold-shock protein that has been implicated in all hallmarks of cancer. Elevated YB-1 protein levels were correlated with poor prognosis in several types of cancers, including breast cancer (BC). In BC, high YB-1 expression is a marker of decreased overall survival (OS) and distant metastasis-free survival across all subtypes. YB-1 is also secreted by different cell types and may act as an extracellular mitogen. Therefore, ou...
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Bone Abstracts
ISSN 2052-1219 (online)
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