Bone Abstracts

Fibrodysplasia ossificans progressiva (FOP) or miyositis ossificans progressiva is a hereditary mesodermal tissue characterized by progressive ossification of striated muscle, tendon, ligament, fasciae, aponeurose and occasionally skin. A single common heterozygous mutation has been identified in the cytoplasmic domain of activin receptor IA/activin-like kinase 2 (ACVR1/ALK2). FOP is very rare with a worldwide prevalence of ~1 case in 2 million individuals. Diagnosis is based ...