Bone Abstracts

Caffeine, a methylxanthine present in coffee, tea, coca-cola and other beverages, is considered to be responsible for an increased risk of osteoporosis in coffee drinkers, however the data from human and experimental studies are inconsistent. The aim of this study was to investigate the effects of a moderate dose of caffeine on the skeletal system of rats with normal and decreased estrogen level (developing osteoporosis due to estrogen deficiency).Caffei...

Results of epidemiological studies indicate that paracetamol use may be a risk factor for fracture. The exact mechanism of paracetamol action remains unclear, but it is known to inhibit COX-2. Orchidectomy-induced androgen deficiency was reported to increase COX-2 expression and prostanoid release in rats. The aim of the present study was to investigate the effect of paracetamol on bone mechanical properties in rats with normal androgen levels and with androgen deficiency indu...

In postmenopausal women, estrogen deficiency not only interferes with the metabolism of the bone tissue, but also adversely affects the cardiovascular system and can cause hypertension. Doxazosin is often used in the treatment of resistant hypertension, especially in patients with renal failure and hyperlipidemia. Vasodilator effect of doxazosin is associated with selective blocking of α1 receptors in the smooth muscle cells of resistance arterioles. The results of epidem...

Objectives: While local gene therapy for bone applications has shown some success in preclinical models, systemic delivery of transgenes to the skeleton remains a considerable challenge. Viral vectors such as adeno-associated viruses (AAVs) have great potential as vectors for systemic transgene delivery and may be adapted for emerging gene editing technologies. Furthermore, AAV vectors can have high efficiency, low immunogenicity, and selective tropism towards different tissue...

Diabetes leads to development of osteoporosis. Experimental type 1 diabetes may be induced by a single dose of streptozotocin (STZ), and nicotinamide (NA) administered 15 min before STZ dose-dependently protects against the STZ action. Coffee drinking, apart of its health benefits, is taken into consideration as an osteoporosis risk factor. Data from human and experimental studies on coffee and caffeine effects on the skeletal system are inconsistent. For example, although oth...