ba0003pp47 | Bone development/growth and fracture repair | ECTS2014
Leotot Julie
, Lebouvier Angelique
, Hernigou Philippe
, Rouard Helene
, Chevallier Nathalie
Human mesenchymal stromal cells (hMSC) have been investigated as a clinical therapy to promote tissue repair. However, the disappearance of grafted cells soon after engraftment suggests that hMSC could principally act as initiators of repair through paracrine mechanisms.The aim of this study was to evaluate the relative contribution of grafted hMSC and host cells in promoting bone tissue repair. We isolated hMSC from three bone marrow (BM) donors, then d...