Bone Abstracts

Children and adolescents with inflammatory bowel disease (IBD) have defects in bone mineral density (BMD) and bone structure that do not completely normalize with clinical remission.The objective of the study was to determine bone turnover marker (BTM) concentrations and factors behind altered bone metabolism in a case-control setting.We measured the bone formation marker PINP and bone resorption markers CTX and TRACP5b in 42 adole...

Objectives: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an autosomal-recessive disorder caused by mutations in the autoimmune regulator gene resulting in insufficient suppression of autoimmunity. The impact of immunological abnormalities and the resulting endocrinopathies on bone health is largely unknown. We performed a comprehensive evaluation of skeletal parameters in a large cohort of adult patients with APECED.Methods:...