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ba0005p425 | Other diseases of bone and mineral metabolism | ECTS2016

IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

Kurozumi Akira , Nakano Kazuhisa , Yamagata Kaoru , Okada Yosuke , Nakayamada Shingo , Tanaka Yoshiya

Objective: Both inflammation and vascular calcification have been known as independent risk factors of cardiovascular events. However, the induction mechanism of vascular calcification by inflammation is still unclear. We here assessed the molecular effects of pro-inflammatory cytokines on vascular smooth muscle cell (VSMC) calcification.Methods: VSMCs from human aorta cultured in osteoblast induction medium (OIM) and stimulated by pro-inflammatory cytok...

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IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

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