Abstract Search

ba0001pp430 | Osteoporosis: treatment | ECTS2013

First in man study of a novel and highly selective cathepsin K inhibitor miv-711 – safety, pharmacokinetics and pharmacodynamics of single ascending oral doses in healthy subjects

Grabowska Urszula , Lindstrom Erik , Jerling Markus , Larsson Torbjorn , Bottiger Disa , Danielson Kerstin , Kristensen Jens D , Edenius Charlotte

Aim: To determine the safety, tolerability, pharmacokinetics and pharmacodynamics of the cathepsin K inhibitor MIV-711.Methods: A double-blind, placebo-controlled, randomized study in 27 healthy subjects of both genders. Single ascending doses 20600 mg were investigated for adverse events, clinical chemistry, vital signs, ECG parameters, pharmacokinetics, and serum levels of CTX-I.Results: MIV-711 was well tolerated with no a...

0 shares

Bone Abstracts

First in man study of a novel and highly selective cathepsin K inhibitor miv-711 – safety, pharmacokinetics and pharmacodynamics of single ascending oral doses in healthy subjects

BiosciAbstracts