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ba0005p193 | Cell biology: osteoclasts and bone resorption | ECTS2016

C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction

Lee Ji-Won , Hoshino Akiyoshi , Saitou Takashi , Inoue Kazuki , Uehara Shunsuke , Kobayashi Yasuhiro , Matsushima Kouji , Imai Yuuki , Iimura Tadahiro

C-C chemokine receptor 5 (CCR5) is a co-receptor of macrophage-tropic viruses including HIV. Epidemiological and pathological findings have reported that functional changes in CCR5 correlate with HIV transmission bone destruction disease. However, the roles of CCR5 in bone pathophysiology have not been well documented.Ccr5-deficient osteoclasts showed decreased bone resorption activity accompanied with disorganized cellular architecture and impa...

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C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction

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