ba0001pp384 | Osteoporosis: pathophysiology and epidemiology | ECTS2013
McCloskey Eugene
, Johansson Helena
, Oden Anders
, Kanis John
Although the optimal requirement of vitamin D for skeletal health in the general community remains uncertain, vitamin D deficiency impairs bone mineralisation, increases bone turnover, accelerates bone loss and increases fracture risk. Seasonal variation in the hip fracture incidenc, reported in several studies, supports a role for vitamin D deficiency in the epidemiology of hip fracture. We hypothesised that if the association is causal, then the amplitude of the seasonal var...