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ba0005p118 | Cancer and bone: basic, translational and clinical | ECTS2016

Menin is a tumor suppressor in bone -- a novel benign jaw tumor mouse model

Lee Sooyeon , Liu Peng , Tschaffon Miriam , Tasdogan Alpaslan , Wittig Rainer , Frappart Lucien , Knoll Jeanette , Bertolino Philippe , Zhang Chang , Tuckermann Jan

Benign jaw tumors including ossifying fibroma (OF) can be often incidentally diagnosed due to their slow-growing and painless characteristics. In cases of massive growing jaw tumors, it can result in deformity of teeth, infection and intracranial complications. Depending on the location of tumor lesion, it may not completely resected and recur after the primary operation, which may require subsequent operations.Molecular mechanisms and the etiology of th...

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ba0003OP27 | Pre-Clinical | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

see PP416....

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ba0003pp416 | Steroid hormones and receptors | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead to multiple side effects including glucocorticoid induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by the glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation of genes is causing side effects.Using conditional and function selective mutant mic...

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Bone Abstracts

Menin is a tumor suppressor in bone -- a novel benign jaw tumor mouse model

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

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