Bone Abstracts

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

Osteoclasts are bone-resorbing multinucleated cells that differentiate from monocyte/macrophage-lineage precursors. Bone destruction and osteoporosis are attributed to excessively activated osteoclasts. Osteoclast differentiation is governed by diverse regulatory processes including nuclear factor-activated T cells c1 (NFATc1) activation in response to RANKL. The mechanism of epigenetic regulation of NFATc1 in osteoclastogenesis not investigated yet. Here we test a hypothesis ...