ba0005p461 | Other diseases of bone and mineral metabolism | ECTS2016
Iundusi Riccardo
, Gasbarra Elena
, Scimeca Manuel
, Pignatale Ilaria
, Bonanno Elena
, Tarantino Umberto
Introduction: Age-related bone diseases, such as osteoarthritis (OA) and osteoporosis (OP), are strongly associated with sarcopenia and muscle fiber atrophy. Potential mechanisms involved in the reduction of skeletal muscle mass during sarcopenia converge on the failure of satellite cells in replacing and repairing damaged muscle fibers. Myostatin and bone morphogenetic proteins (BMPs) are molecules able to regulate muscle mass homeostasis by activating satellite stem cells [4...