ba0003oc6.5 | Osteoporosis treatment and the effects of physical activity | ECTS2014
Gossiel Fatma
, Hoyle Christopher
, McCloskey Eugene
, Walsh Jennifer
, Peel Nicola
, Eastell Richard
Bisphosphonates are used to treat bone disease characterised by increased bone resorption by inhibiting the activity of mature osteoclasts, resulting in decreased bone turnover. Bisphosphonates may reduce the population of osteoclast precursor cells (OPCs). Our aims were to investigate the effect of bisphosphonates on i) OPCs and ii) bone turnover in postmenopausal women with osteoporosis compared with healthy premenopausal women. Participants were 62 postmenopausal women (mea...